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Vaccine skepticism in Germany multiplies with novel COVID vaccines

photo: stilistica.design based on data provided by Civey GmbH

Today, the results of a first representative empirical study of COVID-19 vaccine skeptics, conducted by kENUP Foundation, the Swiss Academies of Arts and Sciences and the EIB Institute, have been published.


  • 13.7 million new vaccine opponents since pandemic onset; 
  • skepticism mostly exacerbated by fears of long-term damage and fast vaccine approval processes, correlates with corona virus denial;
  • 90% of skeptics feel they have no influence over politics, are predominantly AfD-leaning and about 45% attained the lowest level or left secondary school without certification;
  • while new skeptics could be convinced by facts, long-term anti-vaccinationists appear unyielding.


The first representative study of COVID-19 vaccine skeptics, conducted by kENUP Foundation, the Swiss Academies of Arts and Sciences and the EIB Institute, identified the socioeconomic and consumer behavior profile, as well as the dominant values and positions of COVID-19 vaccines skeptics and examined potential strategies to increase willingness to get a COVID-19 vaccine in that cohort.

 

Vaccination is one of the public health measures that has had the greatest impact on the reduction of the burden from infectious diseases. According to the World Health Organization, vaccines prevent up to 3 million deaths worldwide each year. Vaccines are the most important tool in exiting the ongoing COVID-19 pandemic. Yet, anti-vaccination sentiments are highest in Europe compared to other regions in the world, potentially undermining vaccination and herd immunity efforts.

 

Overall, 19.6% of the German population make up the COVID-19 vaccine skeptic group, those unlikely or very unlikely to take the jab once offered to them. Almost 84.2% of that group were not opposed to vaccines before the corona crisis. This means that 13.7 million new skeptics are contributing to the high COVID-19 anti-vaccine sentiment.

 

COVID-19 vaccine skepticism is mainly driven by the fear of long-term damage (66.0%), the fast approval process (54.7%) and fear of adverse health effects (53.0%). It correlates with corona virus denial: 21.7% of vaccine skeptics and 36.8% of long-term anti-vaccinationists disagree that COVID-19 causes serious health problems. Denial that the virus has infected many people worldwide is 21.8% and 40%, respectively for new skeptics and long-term anti-vaccinationists.

 

While 69.3% of all vaccine skeptics claim that they could be convinced to take the COVID-19 vaccine through factual assurances, 69.4% of long-term anti-vaccinationists state that nothing would convince them. On the assurances needed for attitudinal change within the overall cohort, exclusion of long-term damage (52.0%), proven effectiveness (40.8%) and the evidence that genes are not changed (32.0%) top the list. Moreover, neither celebrity endorsement nor prospects of long-distance travel are convincing skeptics to be vaccinated. Vaccine skeptics seem to have more trust in vaccines originating from Germany, the United States, and the United Kingdom. Vaccines from Russia, China and especially India would have low chances to convince skeptics.

 

A prevailing lack of life meaning and political participation defines the cohort of vaccine skeptics: 89.2% feel that they have no influence over politics. Of the long-term anti-vaccinationists, 35.2% express existential fears and financial worries, with life lacking any perspective for 35.6% of them. In terms of political affiliation, the anti-vaccination group is predominantly AfD-leaning (43.0%, far-right), with support of FDP (liberal) and Die Linke (left) also over-represented, while affinity to SPD (centre-left), CDU/CSU (centre-right) and Die Grünen (green) remains significantly underrepresented. Anti-vaccination sentiments are much higher in people of non-Christian religions.

 

Vaccine skeptics predominantly do not work, or if they do, they are not employed but pursue independent activities. 44.8% of them left secondary school without any certification or attained the lowest certification level. The group predominately lives in households with children and in low density areas with lower purchasing power, with a strong spike in the Eastern German States.

 

The classical news channels, including television and curated authoritative content on the internet, do not reach the anti-vaccination group, as their media consumption is dominated by YouTube and Facebook. On the other hand, they are predominantly late adaptors to technology. The group is further characterized by a high affinity to brands, having fun with friends, DIY, and a low kinship to eco-friendly products.


To access the full study, please click here.

The partner's press release can be accessed here.

To access kENUP's businesswire release, please click here.


Governments spent at least €93bn on COVID-19 vaccines and therapeutics during the last 11 months

photo: stilistica.design

  • New figures from kENUP Foundation show extent of public investments in COVID-19 vaccines and therapeutics
  • 95% of funds in support of vaccines, with just 5% allocated to therapeutics
  • Most funding was granted through a novel mechanism: 93% of all public funds were committed through advance market commitments (AMC), e.g. by Operation Warp Speed in the United States, or by the European Commission
  • Geographically, 32% of public funds came from the United States, 24% from the EU and its Member States, and 13% from Japan and South Korea
  • On the vaccine side, 71% of public funding went into products under development by SMEs and MidCaps, with only 18% deployed to large pharmaceutical manufacturers


According to analysis conducted by kENUP Foundation, the public sector has dedicated at least €93bn to COVID-19 vaccines and therapeutics in 2020. More than 95%, about €88.3bn, was spent on vaccine companies. Only 5% of public COVID-19 funds were spent on therapeutics.


Most of the funds, around €86.5bn, were used to conclude advance market commitments (AMCs). In return for the right to buy a specified number of vaccine doses in a given time frame, governments finance part of the upfront costs faced by vaccines producers in the form of AMCs. Just 7% of funds were spent through preferred loans or conventional grants. 


The data also shows the origin of the funding: 32% of funds directed towards vaccine producers come from the US, 24% from the EU, and a total of 13% from the governments of Japan and South Korea. 


For vaccines, exceptionally, governments invested 71% or at least €63.1bn into Small and Medium Enterprises (SMEs) and MidCaps. Only 18% of funds went to big pharma, underlining the importance of SMEs in driving innovation.


Holm Keller, Chairman of kENUP Foundation said: “Public investments have been instrumental in supporting innovation in the fight against the coronavirus. To bridge the time until broad rollout of vaccines, further investment in therapeutics is especially important. In parallel, a dedicated public pandemic preparedness scheme that would make vaccines and therapeutics readily available at lower development costs for any kind of pandemic pathogen is needed”. 


The figures are kENUP’s analysis of publicly available information. They do not include private sector investments. The data was correct on Sunday January 10, 2021.


Please click here for kENUP's press release.


EIB and FIND back innovative plant-based reagent manufacturing in Africa to fight COVID-19 and other endemic diseases 

African manufacturing of proteins needed for the vaccines, rapid testing kits and treatments of COVID-19 and other endemic diseases will be transformed by the extension of Cape Biologix Technologies existing factory in Cape Town, followed by the construction of a new facility in Mauritius. This was announced jointly by the European Investment Bnk (EIB) and the Foundation for Innovative New Diagnostics (FIND) on December 18, 2020. 

The large-scale cGMP manufacturing facility aims to ensure the supply of crucial reagents for the production of 100 million vaccines a month for distribution across Africa, the Caribbean and Pacific. The support will enable Cape Biologix to substantially enlarge manufacturing capacity, expand laboratory processing and build climate controlled hydroponic grow rooms to provide plant-made proteins for prevention, testing and treatment of COVID-19 and other endemic diseases. 

Initiated by kENUP Foundation, new financing from the European Investment Bank (EIB) and FIND (the Foundation for Innovative New Diagnostics) for the EUR 47.5 million project was formally agreed earlier today. The EIB will provide EUR 33.3 million for the specialist manufacturing plant in Mauritius. This has been complemented by EUR 3.2m provided by FIND that is being used to fund the rapid scale-up of the pilot phase production in Cape Town, South Africa.

EIB launches EUR 50 million Africa pharmaceutical manufacturing initiative 

On 17 December 2020, the European Investment Bank launched the first ever scheme to strengthen local production of Active Pharmaceutical Ingredients (API) in Africa and scale up drug manufacturing essential to improve public health. This new initiative is aligned with World Health Organisation goals and the recently announced cooperation between the EIB and WHO to combat COVID-19 and strengthen health system resilience to better face future pandemics. 

Initiated by kENUP Foundation, the EIB’s new EUR 50 million pharmaceutical investment initiative will contribute to reducing dependency on drug imports and address medical supply chain weaknesses linked to COVID-19. The programme will improve availability of specialist drugs and tackle supply chain challenges that currently damage public health across Africa. 

Agreement expands Novavax partnership with Serum Institute of India to increase global delivery of NVX-CoV2373 to over 2 billion annualized doses

Novavax, Inc. announced on September 15, 2020 an amendment to its existing agreement with Serum Institute of India Private Limited (SIIPL) under which SIIPL will also manufacture the antigen component of NVX‑CoV2373, Novavax’ COVID‑19 vaccine candidate. With this agreement, Novavax increases its manufacturing capacity of NVX-CoV2373 to over two billion doses annually, when all planned capacity has been brought online by mid-2021. NVX‑CoV2373 is a stable, prefusion protein made using Novavax’ recombinant protein nanoparticle technology and includes Novavax’ proprietary Matrix‑M™ adjuvant.

Canada to purchase up to 76 million doses of NVX-CoV2373

On August 31, 2020 Novavax Inc.  announced it has reached an agreement in principle with the Government of Canada to supply up to 76 million doses of NVX-CoV2373, Novavax’ COVID-19 vaccine.  Novavax and Canada expect to finalize an advance purchase agreement under which Novavax will supply doses of NVX-CoV2373 to Canada beginning as early as the second quarter of 2021. This purchase arrangement will be subject to licensure of the Novavax vaccine by Health Canada.

EIB to back VPM1002 with € 30 mio

On August 27, 2020 the European Investment Bank has announced that it is backing VPM1002 with a non-dilutive risk-sharing facility of € 30 mio. The loan will finance the late stage (phase III) clinical trial of a new and improved vaccine protecting against Tuberculosis in infants, which is also partly financed by the European & Developing Countries Clinical Trials Partnership (EDCTP). As VPM1002 may potentially have positive effects on COVID-19 infections, a  clinical trail on this secondary exploitation in Germany is currently under way. 

The Bill & Melinda Gates Foundation provides grant to Novavax efficacy trial in South Africa

Novavax Inc. announced on August 17, 2020 the beginning of a Phase 2b clinical trial in South Africa to evaluate the efficacy of NVX-CoV2373, Novavax’ COVID-19 vaccine candidate. The trial is supported in part by a $15 million grant from the Bill & Melinda Gates Foundation. 

The European Commission reaches agreement on AZD1222 with AstraZeneca

On August 14, 2020, the European Commission has reached an agreement with AstraZeneca to purchase AZD1222 as well as to donate to lower and middle income countries or re-direct to other European countries.  

UK Government to procure from Novavax

On August 14, 2020 the UK Government announced the purchase of 60 million doses of NVX-CoV2373 from Novavax. 

Novavax to partner with South Korea

Novavax and Republic of Korea partner on manufacturing and supply of NVX-CoV2373 to global markets, including South Korea. 

UK Government to procure from Novavax

On August 14, 2020 the UK Government announced the purchase of 60 million doses of NVX-CoV2373 from Novavax. 

kENUP Foundation to support Malta's COVID-19 R&I Fund

During a Ceremony held in Malta on July 31, 2020, kENUP Foundation has announced its support of the Republic of Malta's COVID-19 R&I Fund with a donation of € 100.000. 

Operation Warp Speed to invest in Novavax NVX-CoV2373

Novavax announced $1.6 Billion Funding from Operation Warp Speed into Novavax' NVX-CoV2373 vaccine candidate on July 7, 2020.

DoD to invest in Novavax NVX-CoV2373

Novavax announced $ 60 mio. funding for manufacturing of NVX-CoV2373 from the Department of Defense on June 4, 2020. 

EU Malaria Fund to provide financing to mAbCo19 

The EU Malaria Fund has announced on June 3, 2020 that it has approved to finance parts of the development of mAbCo19 .

EU Malaria Fund to support COVAX

The EU Malaria Fund has announced on June 3, 2020 that it has approved to finance parts of the development of Themis' COVAX candidate. 

Merck (US) acquires Themis Bioscience

Themis Bioscience GmbH has been acquired by Merck & Co., Inc. on May 26, 2020. 

CEPI to invest in Novavax NVX-CoV2373 

CEPI announced an investment of up to $ 388 mio. into Novavax' NVX-CoV2373 vaccine candidate on May 11, 2020. 

EIB to finance Pluristem's PLX-PAD

A finance contract on the provision of € 50 Million non-dilutive financing by the European Investment Bank has been signed on April 30, 2020. 

AstraZeneka acquires ChAdOx1 nCoV-19

ChAdOx1 nCoV-19 has been taken over by AstraZeneka in a landmark partnership announced by Oxford University and Vaccitech Limited on April 30, 2020. 
It is now called AZD1222.
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